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mitogen-activated protein kinase 11 (p38-beta)

Target Class
Kinase
Family
CMGC
Official Symbol
MAPK11
Entrez Gene ID
5600
Species
Human
Accession Number
NP_002742.3
Alias Names
MAP kinase 11; MAP kinase p38 beta; MAPK 11; P38B; P38BETA2; PRKM11; SAPK2; SAPK2B; mitogen-activated protein kinase 11; mitogen-activated protein kinase p38 beta; mitogen-activated protein kinase p38-2; p38-2; p38Beta; stress-activated protein kinase 2; stress-activated protein kinase 2b; stress-activated protein kinase-2; stress-activated protein kinase-2b
Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. [provided by RefSeq, Jul 2008]
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Related Group Members: CMGC
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