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fms-related tyrosine kinase 3 (FLT3(ITD))

Target Class
Kinase
Family
TK
Official Symbol
FLT3
Entrez Gene ID
2322
Species
Human
Accession Number
NP_004110.2
Alias Names
CD135; CD135 antigen; FL cytokine receptor; FLK-2; FLK2; STK-1; STK1; fetal liver kinase 2; fms-like tyrosine kinase 3; fms-related tyrosine kinase 3; growth factor receptor tyrosine kinase type III; receptor-type tyrosine-protein kinase FLT3; stem cell tyrosine kinase 1
Background
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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