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Fms-related tyrosine kinase 3 (FLT3)

Target Class
Kinase
Family
Receptor Tyrosine Kinase
Official Symbol
FLT3
Species
Human
Accession Number
NM_004119
Alias Names
CD135; CD135 antigen; FL cytokine receptor; FLK-2; FLK2; STK-1; STK1; fetal liver kinase 2; fms-like tyrosine kinase 3; fms-related tyrosine kinase 3; growth factor receptor tyrosine kinase type III; receptor-type tyrosine-protein kinase FLT3; stem cell tyrosine kinase 1
Background
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: Receptor Tyrosine Kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-0901C3
Assay Measures Background Species Assay Kit
Receptor Phosphorylation U2OS Human 93-0901E3CP16S
Receptor Phosphorylation U2OS Human 93-0901E3CP16M
Receptor Phosphorylation U2OS Human 93-0901E3CP16L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available