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PTK2 protein tyrosine kinase 2 (FAK)

Target Class
Kinase
Family
TK
Official Symbol
PTK2
Entrez Gene ID
5747
Species
Human
Accession Number
NP_722560.1
Alias Names
FADK; FADK 1; FAK; FAK-related non-kinase polypeptide; FAK1; FRNK; PPP1R71; PTK2 protein tyrosine kinase 2; focal adhesion kinase 1; focal adhesion kinase-related nonkinase; p125FAK; pp125FAK; protein phosphatase 1 regulatory subunit 71; protein phosphatase 1, regulatory subunit 71
Background
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010]
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Related Group Members: TK
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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