Find a Product

erb-b2 receptor tyrosine kinase 3

Target Class
Kinase
Family
TK
Official Symbol
ERBB3
Entrez Gene ID
2065
Species
Human
Accession Number
NP_001973.2
Alias Names
ErbB-3; HER3; LCCS2; MDA-BF-1; c-erbB-3; c-erbB3; erbB3-S; lethal congenital contracture syndrome 2; p180-ErbB3; p45-sErbB3; p85-sErbB3; proto-oncogene-like protein c-ErbB-3; receptor tyrosine-protein kinase erbB-3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Background
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
+ Show More


Solution Portfolio

Related Group Members: TK
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
ErbB2/ErbB3 Dimerization U2OS Human 93-1042C3
Dimerization U2OS Human 93-1125C3
Assay Qualified With Assay Measures Background Species Assay Kit
Perjeta Dimerization U2OS Human 93-1042Y3-00095
Perjeta Dimerization U2OS Human 93-1042Y3-00096
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available