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EPH receptor B6 (EPHB6)

Target Class
Kinase
Family
TK
Official Symbol
EPHB6
Entrez Gene ID
2051
Species
Human
Accession Number
NP_004436.2
Alias Names
EPH receptor B6; EphB6; HEP; ephrin type-B receptor 6; tyrosine-protein kinase-defective receptor EPH-6
Background
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands. [provided by RefSeq, Jul 2008]
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Related Group Members: TK
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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