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Ephrin type-B receptor 4 (EphB4)

Target Class
Kinase
Family
Receptor Tyrosine Kinase
Official Symbol
EphB4
Species
Human
Accession Number
NM_004444
Alias Names
EPH receptor B4; EphB4; HTK; MYK1; TYRO11; ephrin receptor EphB4; ephrin type-B receptor 4; hepatoma transmembrane kinase; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; tyrosine-protein kinase TYRO11; tyrosine-protein kinase receptor HTK
Background
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: Receptor Tyrosine Kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-0468C3
Assay Measures Background Species Assay Kit
Receptor Phosphorylation U2OS Human 93-0468E3CP16S
Receptor Phosphorylation U2OS Human 93-0468E3CP16M
Receptor Phosphorylation U2OS Human 93-0468E3CP16L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available Available