Targets / Kinase / EPHA8

EPH receptor A8 (EPHA8)

Target Class
Kinase
Family
TK
Official Symbol
EPHA8
Entrez Gene ID
2046
Species
Human
Accession Number
NP_065387.1
Alias Names
EEK; EK3; EPH receptor A8; EPH- and ELK-related kinase; EPH- and ELK-related tyrosine kinase; EPH-like kinase 3; EphA8; HEK3; ephrin type-A receptor 8; hydroxyaryl-protein kinase; protein-tyrosine kinase; tyrosine-protein kinase receptor EEK; tyrosylprotein kinase
Background
This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008]
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Related Group Members: TK
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