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EPH receptor A3 (EPHA3)

Target Class
Kinase
Family
TK
Official Symbol
EPHA3
Entrez Gene ID
2042
Species
Human
Accession Number
NP_005224.2
Alias Names
EK4; EPH receptor A3; EPH-like kinase 4; ETK; ETK1; EphA3; HEK; HEK4; TYRO4; TYRO4 protein tyrosine kinase; eph-like tyrosine kinase 1; ephrin type-A receptor 3; human embryo kinase 1; tyrosine-protein kinase receptor ETK1
Background
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
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Related Group Members: TK
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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