Targets / Kinase / EPHA1

EPH receptor A1 (EPHA1)

Target Class
Kinase
Family
TK
Official Symbol
EPHA1
Entrez Gene ID
2041
Species
Human
Accession Number
NP_005223.4
Alias Names
EPH; EPH receptor A1; EPHT; EPHT1; EphA1; eph tyrosine kinase 1; ephrin type-A receptor 1; erythropoietin-producing hepatoma amplified sequence; erythropoietin-producing hepatoma receptor; hEpha1; oncogene EPH; soluble EPHA1 variant 1; soluble EPHA1 variant 2; tyrosine-protein kinase receptor EPH
Background
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]
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