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Discoidin domain receptor 1 (CD167a)

Target Class
Kinase
Family
Receptor Tyrosine Kinase
Official Symbol
DDR1
Species
Human
Accession Number
NM_013993.2
Alias Names
CAK; CD167; CD167 antigen-like family member A; DDR; EDDR1; HGK2; MCK10; NEP; NTRK4; PTK3; PTK3A; PTK3A protein tyrosine kinase 3A; RTK6; TRKE; cell adhesion kinase; discoidin domain receptor family, member 1; discoidin domain receptor tyrosine kinase 1; epithelial discoidin domain-containing receptor 1; mammary carcinoma kinase 10; neuroepithelial tyrosine kinase; neurotrophic tyrosine kinase, receptor, type 4; protein-tyrosine kinase RTK-6; tyrosine kinase DDR; tyrosine-protein kinase CAK
Background
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
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Solution Portfolio

Related Group Members: Receptor Tyrosine Kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-0894C3
Assay Measures Background Species Assay Kit
Receptor Phosphorylation U2OS Human 93-0894E3CP16S
Receptor Phosphorylation U2OS Human 93-0894E3CP16M
Receptor Phosphorylation U2OS Human 93-0894E3CP16L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available Available