Targets / Kinase / CDC2L1

cyclin-dependent kinase 11B (CDC2L1)

Target Class
Kinase
Family
CMGC
Official Symbol
CDK11B
Entrez Gene ID
984
Species
Human
Accession Number
NP_277023.1
Alias Names
CDC-related protein kinase p58; CDC2L1; CDK11; CDK11-p110; CDK11-p46; CDK11-p58; CLK-1; PITSLRE serine/threonine-protein kinase CDC2L1; PITSLREA; PK58; cell division cycle 2-like 1 (PITSLRE proteins); cell division cycle 2-like protein kinase 1; cell division protein kinase 11B; cyclin-dependent kinase 11B; galactosyltransferase-associated protein kinase p58/GTA; p58; p58 CLK-1; p58CDC2L1; p58CLK-1
Background
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported. [provided by RefSeq, Jul 2008]
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Related Group Members: CMGC
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