Find a Product

v-raf murine sarcoma viral oncogene homolog B1 (BRAF)

Target Class
Kinase
Family
TKL
Official Symbol
BRAF
Entrez Gene ID
673
Species
Human
Accession Number
NP_004324.2
Alias Names
94 kDa B-raf protein; B-RAF1; B-Raf proto-oncogene serine/threonine-protein kinase (p94); BRAF1; NS7; RAFB1; murine sarcoma viral (v-raf) oncogene homolog B1; p94; proto-oncogene B-Raf; serine/threonine-protein kinase B-raf; v-raf murine sarcoma viral oncogene homolog B1
Background
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008]
+ Show More


Solution Portfolio

Related Group Members: TKL
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available