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bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2)

Target Class
Kinase
Family
TKL
Official Symbol
BMPR2
Entrez Gene ID
659
Species
Human
Accession Number
NP_001195.2
Alias Names
BMP type II receptor; BMP type-2 receptor; BMPR-2; BMPR-II; BMPR3; BMR2; BRK-3; PPH1; T-ALK; bone morphogenetic protein receptor type II; bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); primary pulmonary hypertension 1; type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4
Background
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: TKL
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
ACVRL1/BMPR2 Dimerization U2OS Human 93-0962C3
BMPR1A/BMPR2 Dimerization U2OS Human 93-1006C3
BMPR1B/BMPR2 Dimerization U2OS Human 93-1053C3
ACVR1B/BMPR2 Dimerization U2OS Human 93-1072C3
Assay Measures Background Species Assay Kit
ACVRL1/BMPR2 Dimerization U2OS Human 93-0962E3CP22S
ACVRL1/BMPR2 Dimerization U2OS Human 93-0962E3CP22M
ACVRL1/BMPR2 Dimerization U2OS Human 93-0962E3CP22L
BMPR1A/BMPR2 Dimerization U2OS Human 93-1006E3CP0S
BMPR1A/BMPR2 Dimerization U2OS Human 93-1006E3CP0M
BMPR1A/BMPR2 Dimerization U2OS Human 93-1006E3CP0L
ACVR1B/BMPR2 Dimerization U2OS Human 93-1072E3CP5S
ACVR1B/BMPR2 Dimerization U2OS Human 93-1072E3CP5M
ACVR1B/BMPR2 Dimerization U2OS Human 93-1072E3CP5L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available