Targets / Kinase / BMPR1A

bone morphogenetic protein receptor, type IA (BMPR1A)

Target Class
Kinase
Family
TKL
Official Symbol
BMPR1A
Entrez Gene ID
657
Species
Human
Accession Number
NP_004320.2
Alias Names
10q23del; ACVRLK3; ALK-3; ALK3; BMP type-1A receptor; BMPR-1A; CD292; SKR5; activin A receptor, type II-like kinase 3; activin receptor-like kinase 3; bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type IA; serine/threonine-protein kinase receptor R5
Background
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: TKL
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Cell Lines
Assay Measures Background Species Cell Line
Dimerization U2OS Human 93-1169C3
BMPR1A/ACVR2 Dimerization U2OS Human 93-1037C3
BMPR1A/ACVR2B Dimerization U2OS Human 93-1038C3
BMPR1A/BMPR2 Dimerization U2OS Human 93-1006C3
Ready to Use eXpress Kits
Assay Measures Background Species Assay Kit
BMPR1A/BMPR2 Dimerization U2OS Human 93-1006E3CP0M
BMPR1A/BMPR2 Dimerization U2OS Human 93-1006E3CP0L
BMPR1A/ACVR2 Dimerization U2OS Human 93-1037E3CP5M
BMPR1A/ACVR2 Dimerization U2OS Human 93-1037E3CP5L
LeadHunter Screening & Profiling Services
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available