Targets / Kinase / AKT1
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v-akt murine thymoma viral oncogene homolog 1 (AKT1)

Target Class
Kinase
Family
AGC
Official Symbol
AKT1
Entrez Gene ID
207
Species
Human
Accession Number
NP_005154.2
Alias Names
AKT; PKB; PKB alpha; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA; RAC-PK-alpha; RAC-alpha serine/threonine-protein kinase; protein kinase B alpha; proto-oncogene c-Akt; rac protein kinase alpha; v-akt murine thymoma viral oncogene homolog 1
Background
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
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