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activin A receptor type II-like 1 (ACVRL1)

Target Class
Kinase
Family
TKL
Official Symbol
ACVRL1
Entrez Gene ID
94
Species
Human
Accession Number
NP_000011.1
Alias Names
ACVRLK1; ALK-1; ALK1; HHT; HHT2; ORW2; SKR3; TGF-B superfamily receptor type I; TSR-I; activin A receptor type II-like 1; activin A receptor, type II-like kinase 1; activin receptor-like kinase 1; serine/threonine-protein kinase receptor R3
Background
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: TKL
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
ACVRL1/BMPR2 Dimerization U2OS Human 93-0962C3
ACVRL1/ACVR2 Dimerization U2OS Human 93-0963C3
ACVRL1/ACVR2B Dimerization U2OS Human 93-0964C3
Assay Measures Background Species Assay Kit
ACVRL1/BMPR2 Dimerization U2OS Human 93-0962E3CP22S
ACVRL1/BMPR2 Dimerization U2OS Human 93-0962E3CP22M
ACVRL1/BMPR2 Dimerization U2OS Human 93-0962E3CP22L
ACVRL1/ACVR2 Dimerization U2OS Human 93-0963E3CP0S
ACVRL1/ACVR2 Dimerization U2OS Human 93-0963E3CP0M
ACVRL1/ACVR2 Dimerization U2OS Human 93-0963E3CP0L
ACVRL1/ACVR2B Dimerization U2OS Human 93-0964E3CP22S
ACVRL1/ACVR2B Dimerization U2OS Human 93-0964E3CP22M
ACVRL1/ACVR2B Dimerization U2OS Human 93-0964E3CP22L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available