activin A receptor, type IIB (ACVR2B)

Target Class
Official Symbol
Entrez Gene ID
Accession Number
Alias Names
ACTRIIB; ActR-IIB; HTX4; activin A receptor, type IIB; activin receptor type-2B
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
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Related Group Members: TKL

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Assay Measures Background Species Cell Line
ACVR1C/ACVR2B Dimerization U2OS Human 93-1047C3
ACVRL1/ACVR2B Dimerization U2OS Human 93-0964C3
BMPR1A/ACVR2B Dimerization U2OS Human 93-1038C3
BMPR1B/ACVR2B Dimerization U2OS Human 93-1052C3
TGFBR1/ACVR2B Dimerization U2OS Human 93-1046C3
Assay Measures Background Species Assay Kit
ACVRL1/ACVR2B Dimerization U2OS Human 93-0964E3CP22M
ACVRL1/ACVR2B Dimerization U2OS Human 93-0964E3CP22L
ACVR1C/ACVR2B Dimerization U2OS Human 93-1047E3CP5M
ACVR1C/ACVR2B Dimerization U2OS Human 93-1047E3CP5L
TGFBR1/ACVR2B Dimerization U2OS Human 93-1046E3CP5M
TGFBR1/ACVR2B Dimerization U2OS Human 93-1046E3CP5L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan