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activin A receptor, type IIB (ACVR2B)

Target Class
Kinase
Family
TKL
Official Symbol
ACVR2B
Entrez Gene ID
93
Species
Human
Accession Number
NP_001097.2
Alias Names
ACTRIIB; ActR-IIB; HTX4; activin A receptor, type IIB; activin receptor type-2B
Background
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: TKL
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
ACVRL1/ACVR2B Dimerization U2OS Human 93-0964C3
TGFBR1/ACVR2B Dimerization U2OS Human 93-1046C3
BMPR1A/ACVR2B Dimerization U2OS Human 93-1038C3
ACVR1C/ACVR2B Dimerization U2OS Human 93-1047C3
BMPR1B/ACVR2B Dimerization U2OS Human 93-1052C3
Assay Measures Background Species Assay Kit
ACVRL1/ACVR2B Dimerization U2OS Human 93-0964E3CP22S
ACVRL1/ACVR2B Dimerization U2OS Human 93-0964E3CP22M
ACVRL1/ACVR2B Dimerization U2OS Human 93-0964E3CP22L
ACVR1C/ACVR2B Dimerization U2OS Human 93-1047E3CP5S
ACVR1C/ACVR2B Dimerization U2OS Human 93-1047E3CP5M
ACVR1C/ACVR2B Dimerization U2OS Human 93-1047E3CP5L
TGFBR1/ACVR2B Dimerization U2OS Human 93-1046E3CP5S
TGFBR1/ACVR2B Dimerization U2OS Human 93-1046E3CP5M
TGFBR1/ACVR2B Dimerization U2OS Human 93-1046E3CP5L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available