Biological Information | |
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Background Information: | AAK1 (AP2 Associated Kinase 1) belongs to the SNF1 subfamily of serine/threonine protein kinases. This kinase is detected in brain, heart and liver, and plays an important role in regulating the clathrin-mediated endocytosis of the rabies virus, facilitating infection. Inhibitors of AAK1 are being studied as candidate therapeutics to disrupt the entry of viruses, including SARS-CoV-2, into target cells. It is also involved in positive regulation of Notch pathway signaling in mammals. [provided by RefSeq, Aug 2020] |
Target Class: | Kinase |
Accession Number: | NM_080836.2 |
Target Name: | AAK1 |
Target Aliases: | AP2 Associated Kinase 1, KIAA1048, AP2-Associated Protein Kinase, Adaptor-Associated Kinase 1 |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 1 year at -70°C |
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AAK1, active
10 µg of active AAK1. N-terminal 6His-tagged, recombinant fragment of human AAK1.
Datasheets
16-043x Datasheet
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