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Vasoactive intestinal peptide receptor 1 (VPAC1)

Target Class
GPCR
Family
VIP and PACAP
Official Symbol
VIPR1
Species
Human
Accession Number
NM_004624
Alias Names
HVR1; II; PACAP type II receptor; PACAP-R-2; PACAP-R2; RDC1; V1RG; VAPC1; VIP and PACAP receptor 1; VIP receptor, type I; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R; pituitary adenylate cyclase activating polypeptide receptor, type II; vasoactive intestinal peptide receptor 1; vasoactive intestinal polypeptide receptor 1
Background
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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Solution Portfolio

Related Family Members:

VIP and PACAP
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Arrestin Assays
?

DiscoveRx PathHunter ß-Arrestin GPCR assays are a cell-based functional assay that quantitatively measures GPCR activation through ß-Arrestin recruitment to activated GPCRs. This offers a simple, yet powerful screening and profiling platform that can be used for almost all Gi-, Gs-, or Gq-coupled receptor. Learn more about our Arrestin Assays.

Assay Readout Background Cell Lines
?

DiscoveRx offers stable and validated cell lines of unsurpassed quality and leading performance, engineered using our proprietary EFC technology. These engineered cell lines form the basis of our cell-based assays for a broad range of target classes in a variety of cell backgrounds, ideal for screening and profiling both small molecules and biologics. Learn more about our Cell Lines.

Assay Ready Kits
?

DiscoveRx Assay Ready kits are ready-to-ship, ready-to-use kits that contain all the necessary reagents to perform a functional whole-cell assay including frozen pre-validated cells, detection reagents, media and plates, with a simple thaw-plate-read protocol. DiscoveRx offers a variety of Assay Ready kits. Learn more about our Assay Ready Kits.

Orthologs Services
?

DiscoveRx offers a variety of service options designed to support you at every stage of drug development. We offer screening and profiling services for small molecules and biologics, using DiscoveRx cell lines anchored in the EFC and competition binding technology platforms. We can develop custom assay solutions tailored to meet your needs and provide scale up options for our cell lines and supporting components. Learn more about DiscoveRx Services.

β-Arrestin-2 CHO-K1 93-0316C2 (β-Arrestin/Ca2+) eXpress
mouse
rat
Yes
Second Messenger
?

GPCR activation is often accompanied by the release of second messenger signaling molecules such as cAMP, Calcium, IP3 and cGMP, based on its G-protein binding partners. DiscoveRx offers a variety of cell lines and kits to study these second messenger signaling molecules as a measure of GPCR activity. Learn more about our Second Messengers.

Assay Readout Background Cell Lines
?

DiscoveRx offers stable and validated cell lines of unsurpassed quality and leading performance, engineered using our proprietary EFC technology. These engineered cell lines form the basis of our cell-based assays for a broad range of target classes in a variety of cell backgrounds, ideal for screening and profiling both small molecules and biologics. Learn more about our Cell Lines.

Assay Ready Kits
?

DiscoveRx Assay Ready kits are ready-to-ship, ready-to-use kits that contain all the necessary reagents to perform a functional whole-cell assay including frozen pre-validated cells, detection reagents, media and plates, with a simple thaw-plate-read protocol. DiscoveRx offers a variety of Assay Ready kits. Learn more about our Assay Ready Kits.

Orthologs Services
?

DiscoveRx offers a variety of service options designed to support you at every stage of drug development. We offer screening and profiling services for small molecules and biologics, using DiscoveRx cell lines anchored in the EFC and competition binding technology platforms. We can develop custom assay solutions tailored to meet your needs and provide scale up options for our cell lines and supporting components. Learn more about DiscoveRx Services.

cAMP CHO-K1 95-0093C2 eXpress
Yes
Receptor Internalization
?

DiscoveRx PathHunter GPCR Internalization Assays are a non-imaging, antibody-free method to measure GPCR endocytosis in intact cells. This simple, chemiluminescent based assay is able to detect total GPCR internalization and activated GPCR internalization. Learn more about our Receptor Internalization.

Assay Readout Background Cell Lines
?

DiscoveRx offers stable and validated cell lines of unsurpassed quality and leading performance, engineered using our proprietary EFC technology. These engineered cell lines form the basis of our cell-based assays for a broad range of target classes in a variety of cell backgrounds, ideal for screening and profiling both small molecules and biologics. Learn more about our Cell Lines.

Assay Ready Kits
?

DiscoveRx Assay Ready kits are ready-to-ship, ready-to-use kits that contain all the necessary reagents to perform a functional whole-cell assay including frozen pre-validated cells, detection reagents, media and plates, with a simple thaw-plate-read protocol. DiscoveRx offers a variety of Assay Ready kits. Learn more about our Assay Ready Kits.

Orthologs Services
?

DiscoveRx offers a variety of service options designed to support you at every stage of drug development. We offer screening and profiling services for small molecules and biologics, using DiscoveRx cell lines anchored in the EFC and competition binding technology platforms. We can develop custom assay solutions tailored to meet your needs and provide scale up options for our cell lines and supporting components. Learn more about DiscoveRx Services.

Internalization U2OS 93-0739C3 eXpress
Yes
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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