Prostaglandin E receptor 4 (subtype EP4) (EP4)
- Target Class
- GPCR
- Family
- Prostanoid
- Official Symbol
- PTGER4
- Species
- Human
- Accession Number
- AY429109
- Alias Names
- EP4; EP4R; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); prostaglandin E2 receptor EP4 subtype; prostanoid EP4 receptor
- Background
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
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Solution Portfolio
Related Family Members:
Prostanoid
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
HEK 293 |
Human |
93-0304C1 |
| Internalization |
U2OS |
Human |
93-0772C3 |
| β-Arrestin |
U2OS |
Human |
93-0304C3 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
| |
|
|
|
Available |
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