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Prostaglandin E receptor 4 (subtype EP4) (EP4)

Target Class
GPCR
Family
Prostanoid
Official Symbol
PTGER4
Species
Human
Accession Number
AY429109
Alias Names
EP4; EP4R; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); prostaglandin E2 receptor EP4 subtype; prostanoid EP4 receptor
Background
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Prostanoid
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin HEK 293 Human 93-0304C1
β-Arrestin U2OS Human 93-0304C3
Internalization U2OS Human 93-0772C3
Assay Readout Background Species Assay Kit
β-Arrestin HEK 293 Human 93-0304E1CP0S
β-Arrestin HEK 293 Human 93-0304E1CP0M
β-Arrestin HEK 293 Human 93-0304E1CP0L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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