Find a Product

Platelet activating receptor (PAF)

Target Class
GPCR
Family
Platelet-activating factor
Official Symbol
PTAFR
Species
Human
Accession Number
NM_000952.4
Alias Names
PAF-R; PAFR; platelet-activating factor receptor
Background
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
+ Show More

Solution Portfolio

Related Family Members:

Platelet-activating factor
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout ▲BackgroundSpeciesCell Line
cAMPCHO-K1Human95-0091C2
InternalizationU2OSHuman93-0680C3
β-ArrestinCHO-K1Human93-0236C2
 
Assay Readout ▲BackgroundSpeciesAssay Kit
β-ArrestinCHO-K1Human93-0236E2CP0S
β-ArrestinCHO-K1Human93-0236E2CP0M
β-ArrestinCHO-K1Human93-0236E2CP0L
 
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
The DiscoveRx Advantage:
Access your Target with Three Signaling Platforms