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Platelet activating receptor (PAF)

Target Class
Platelet-activating factor
Official Symbol
Accession Number
Alias Names
PAF-R; PAFR; platelet-activating factor receptor
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
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Solution Portfolio

Related Family Members:

Platelet-activating factor

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family

Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0236C2
Internalization U2OS Human 93-0680C3
cAMP CHO-K1 Human 95-0091C2
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0236E2CP0S
β-Arrestin CHO-K1 Human 93-0236E2CP0M
β-Arrestin CHO-K1 Human 93-0236E2CP0L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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