Melatonin receptor 1A (MT1)
- Target Class
- GPCR
- Family
- Melatonin
- Official Symbol
- MTNR1A
- Species
- Human
- Accession Number
- NM_005958
- Alias Names
- MEL-1A-R; MT1; mel1a receptor; melatonin receptor 1A; melatonin receptor type 1A
- Background
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]
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Solution Portfolio
Related Family Members:
Melatonin
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| cAMP |
CHO-K1 |
Human |
95-0086C2 |
| β-Arrestin |
CHO-K1 |
Human |
93-0951C2 |
| Internalization |
DLD1 |
Human |
93-0847C13 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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