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Melatonin receptor 1A (MT1)

Target Class
GPCR
Family
Melatonin
Official Symbol
MTNR1A
Species
Human
Accession Number
NM_005958
Alias Names
MEL-1A-R; MT1; mel1a receptor; melatonin receptor 1A; melatonin receptor type 1A
Background
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Melatonin
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
Internalization DLD1 Human 93-0847C13
cAMP CHO-K1 Human 95-0086C2
β-Arrestin CHO-K1 Human 93-0951C2
Assay Readout Background Species Assay Kit
cAMP CHO-K1 Human 95-0086E2CP2S
cAMP CHO-K1 Human 95-0086E2CP2M
cAMP CHO-K1 Human 95-0086E2CP2L
β-Arrestin CHO-K1 Human 93-0951E2CP2S
β-Arrestin CHO-K1 Human 93-0951E2CP2M
β-Arrestin CHO-K1 Human 93-0951E2CP2L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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