Sphingosine 1-phosphate receptor 1 (mS1P1)
- Target Class
- GPCR
- Family
- Lysophospholipid (S1P)
- Official Symbol
- mEDG1
- Species
- Mouse
- Accession Number
- NM_007901
- Alias Names
- AI849002; Edg1; Lpb1; S1P receptor 1; S1P receptor Edg-1; S1p; S1p1; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation sphingolipid G-protein-coupled receptor 1; lysophospholipid receptor B1; sphingosine 1-phosphate receptor 1; sphingosine 1-phosphate receptor Edg-1; sphingosine-1-phosphate receptor 1
- Background
This gene encodes a G-protein-coupled receptor bound by the lysophospholipid, sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. This receptor is highly expressed in T and B lymphocytes, and it plays a role in T cell and B cell export from peripheral lymphoid organs. This protein is bound and downregulated by FTY720, an exogenous immunosuppressant drug studied in mouse disease models for multiple sclerosis in humans. [provided by RefSeq, Jan 2010]
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Solution Portfolio
Related Family Members:
Lysophospholipid (S1P)
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
CHO-K1 |
Mouse |
93-0476C2 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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