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Chemokine (C-X-C motif) receptor 4 (mCXCR4)

Target Class
GPCR
Family
Chemokine
Official Symbol
mCXCR4
Species
Mouse
Accession Number
NM_009911.2
Alias Names
C-X-C chemokine receptor type 4; CD184; CXC-R4; CXCR-4; Cmkar4; LESTR; PB-CKR; PBSF/SDF-1; SDF-1 receptor; Sdf1r; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C) receptor 4; chemokine receptor 4; fusin; leukocyte-derived seven transmembrane domain receptor; leukocyte-expressed seven-transmembrane-domain; pre-B-cell-derived chemokine receptor; stromal cell-derived factor 1 receptor
Background
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.
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Solution Portfolio

Related Family Members:

Chemokine
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin U2OS Mouse 93-0481C3
Assay Readout Background Species Assay Kit
β-Arrestin U2OS Mouse 93-0481E3MCP5S
β-Arrestin U2OS Mouse 93-0481E3MCP5M
β-Arrestin U2OS Mouse 93-0481E3MCP5L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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