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Melanocortin receptor 1 (MC1)

Target Class
GPCR
Family
Melanocortin
Official Symbol
MC1R
Species
Human
Accession Number
NM_002386
Alias Names
CMM5; MC1-R; MSH-R; SHEP2; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); melanocyte-stimulating hormone receptor; melanotropin receptor
Background
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Melanocortin
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout ▲BackgroundSpeciesCell Line
cAMPCHO-K1Human95-0111C2
β-ArrestinU2OSHuman93-0861C3
 
Assay Readout ▲BackgroundSpeciesAssay Kit
β-ArrestinU2OSHuman93-0861E3CP5S
β-ArrestinU2OSHuman93-0861E3CP5M
β-ArrestinU2OSHuman93-0861E3CP5L
 
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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