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Metabotropic glutamate receptor 1 (mGlu1)

Target Class
GPCR
Family
Metabotropic glutamate
Official Symbol
GRM1
Species
Human
Accession Number
NM_000838.2
Alias Names
GPRC1A; GRM1A; MGLUR1; MGLUR1A; glutamate receptor, metabotropic 1; mGlu1; metabotropic glutamate receptor 1
Background
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Metabotropic glutamate
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
Calcium U2OS Human 95-1021C3
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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