G-protein coupled receptor 75 (GPR75)
- Target Class
- GPCR
- Family
- Class A Orphan
- Official Symbol
- GPR75
- Species
- Human
- Accession Number
- NM_006794
- Alias Names
- G protein-coupled receptor 75; GPRchr2; WI31133; probable G-protein coupled receptor 75
- Background
GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM, Jul 2002] Some recent data have shown that GPR75 could be a novel target in diseases associated with metabolic syndrome including obesity, dyslipidemia, diabetes, cardiovascular disease, and cerebrovascular disease. 20-HETE, which is the metabolic product of the ω-hydroxylation of arachidonic acid by cytochrome P450 (CYP) 4A and 4F isozymes, has been proposed as the endogenous ligand of GPR75. [provided by ScienceDirect, Jan 2022]
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Solution Portfolio
Related Family Members:
Class A Orphan
?
DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
CHO-K1 |
Human |
93-0363C2A |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
| |
|
|
|
Available |
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