G-protein coupled receptor 75 (GPR75)

Target Class
Class A Orphan
Official Symbol
Accession Number
Alias Names
G protein-coupled receptor 75; GPRchr2; WI31133; probable G-protein coupled receptor 75
GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM, Jul 2002] Some recent data have shown that GPR75 could be a novel target in diseases associated with metabolic syndrome including obesity, dyslipidemia, diabetes, cardiovascular disease, and cerebrovascular disease. 20-HETE, which is the metabolic product of the ω-hydroxylation of arachidonic acid by cytochrome P450 (CYP) 4A and 4F isozymes, has been proposed as the endogenous ligand of GPR75. [provided by ScienceDirect, Jan 2022]
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Solution Portfolio

Related Family Members:

Class A Orphan

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family

Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0363C2A
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0363E2ACP1M
β-Arrestin CHO-K1 Human 93-0363E2ACP1L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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