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G protein-coupled estrogen receptor 1 (GPER)

Target Class
GPCR
Family
Estrogen (G protein coupled) receptor
Official Symbol
GPR30
Species
Human
Accession Number
NM_001505
Alias Names
CEPR; CMKRL2; DRY12; FEG-1; G protein-coupled estrogen receptor 1; G protein-coupled receptor 30; G-protein coupled estrogen receptor 1; G-protein coupled receptor 30; GPCR-Br; GPR30; IL8-related receptor DRY12; LERGU; LERGU2; LyGPR; chemoattractant receptor-like 2; chemokine receptor-like 2; constitutively expressed peptide-like receptor; flow-induced endothelial G-protein coupled receptor 1; heptahelix receptor; leucine rich protein in GPR30 3'UTR; lymphocyte-derived G-protein coupled receptor; mER; membrane estrogen receptor
Background
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Estrogen (G protein coupled) receptor
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout ▲BackgroundSpeciesAssay Kit
β-ArrestinCHO-K1Human93-0373E2ACP2S
β-ArrestinCHO-K1Human93-0373E2ACP2M
β-ArrestinCHO-K1Human93-0373E2ACP2L
 
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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