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G protein-coupled estrogen receptor 1 (GPER)

Target Class
GPCR
Family
Estrogen (G protein coupled) receptor
Official Symbol
GPR30
Species
Human
Accession Number
NM_001505
Alias Names
CEPR; CMKRL2; DRY12; FEG-1; G protein-coupled estrogen receptor 1; G protein-coupled receptor 30; G-protein coupled estrogen receptor 1; G-protein coupled receptor 30; GPCR-Br; GPR30; IL8-related receptor DRY12; LERGU; LERGU2; LyGPR; chemoattractant receptor-like 2; chemokine receptor-like 2; constitutively expressed peptide-like receptor; flow-induced endothelial G-protein coupled receptor 1; heptahelix receptor; leucine rich protein in GPR30 3'UTR; lymphocyte-derived G-protein coupled receptor; mER; membrane estrogen receptor
Background
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Estrogen (G protein coupled) receptor
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0373C2A
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0373E2ACP2S
β-Arrestin CHO-K1 Human 93-0373E2ACP2M
β-Arrestin CHO-K1 Human 93-0373E2ACP2L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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