GLP2R -

Targets

Glucagon-like peptide receptor 2 (GLP-2)

Target Class

GPCR

Family

Glucagon

Official Symbol

GLP2R

Species

Human

Accession Number

NM_004246.1

Alias Names

GLP-2 receptor; GLP-2-R; GLP-2R; glucagon-like peptide 2 receptor

Background

The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor ans GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R). [provided by RefSeq, Jul 2008]

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Related Family Members:

Glucagon

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