Glucagon-like peptide receptor 2 (GLP-2)
- Target Class
- GPCR
- Family
- Glucagon
- Official Symbol
- GLP2R
- Species
- Human
- Accession Number
- NM_004246.1
- Alias Names
- GLP-2 receptor; GLP-2-R; GLP-2R; glucagon-like peptide 2 receptor
- Background
The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor ans GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R). [provided by RefSeq, Jul 2008]
+ Show More
Solution Portfolio
Related Family Members:
Glucagon
?
DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
Assay Readout |
Background |
Species |
Cell Line |
β-Arrestin |
CHO-K1 |
Human |
93-0572C2 |
Internalization |
U2OS |
Human |
93-0750C3 |
cAMP |
CHO-K1 |
Human |
95-0112C2 |
Assay Qualified With |
Assay Measures |
Background |
Species |
Assay Kit |
GLP-2 |
β-Arrestin |
CHO-K1 |
Human |
93-0572Y2-00133 |
GLP-2 |
β-Arrestin |
CHO-K1 |
Human |
93-0572Y2-00134 |
KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
|
|
|
|
Available |
|
The DiscoveRx Advantage:
Access your Target with Three Signaling Platforms