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Glucagon-like peptide receptor 2 (GLP-2)

Target Class
GPCR
Family
Glucagon
Official Symbol
GLP2R
Species
Human
Accession Number
NM_004246.1
Alias Names
GLP-2 receptor; GLP-2-R; GLP-2R; glucagon-like peptide 2 receptor
Background
The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor ans GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R). [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Glucagon
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0572C2
Internalization U2OS Human 93-0750C3
cAMP CHO-K1 Human 95-0112C2
Assay Readout Background Species Assay Kit
cAMP CHO-K1 Human 95-0112E2CP2S
cAMP CHO-K1 Human 95-0112E2CP2M
cAMP CHO-K1 Human 95-0112E2CP2L
β-Arrestin CHO-K1 Human 93-0572E2CP2S
β-Arrestin CHO-K1 Human 93-0572E2CP2M
β-Arrestin CHO-K1 Human 93-0572E2CP2L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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