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Galanin receptor 2 (GALR2)

Target Class
GPCR
Family
Galanin
Official Symbol
GALR2
Species
Human
Accession Number
NM_003857
Alias Names
GAL2-R; GALNR2; GALR-2; galanin receptor 2; galanin receptor type 2
Background
Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Galanin
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0759C2
Calcium CHO-K1 Human 95-1010C2
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0759E2CP2S
β-Arrestin CHO-K1 Human 93-0759E2CP2M
β-Arrestin CHO-K1 Human 93-0759E2CP2L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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