Endothelin receptor type B (ETB)
- Target Class
- GPCR
- Family
- Endothelin
- Official Symbol
- EDNRB
- Species
- Human
- Accession Number
- NM_000115.2
- Alias Names
- ABCDS; ET-B; ET-BR; ETB; ETBR; ETRB; HSCR; HSCR2; WS4A; endothelin B receptor; endothelin receptor non-selective type; endothelin receptor type B
- Background
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
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Solution Portfolio
Related Family Members:
Endothelin
?
DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
CHO-K1 |
Human |
93-0593C2 |
| Internalization |
U2OS |
Human |
93-0874C3 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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