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Endothelin receptor type B (ETB)

Target Class
GPCR
Family
Endothelin
Official Symbol
EDNRB
Species
Human
Accession Number
NM_000115.2
Alias Names
ABCDS; ET-B; ET-BR; ETB; ETBR; ETRB; HSCR; HSCR2; WS4A; endothelin B receptor; endothelin receptor non-selective type; endothelin receptor type B
Background
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
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Solution Portfolio

Related Family Members:

Endothelin
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0593C2
Internalization U2OS Human 93-0874C3
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0593E2CP0S
β-Arrestin CHO-K1 Human 93-0593E2CP0M
β-Arrestin CHO-K1 Human 93-0593E2CP0L
Internalization U2OS Human 93-0874E3CP0S
Internalization U2OS Human 93-0874E3CP0M
Internalization U2OS Human 93-0874E3CP0L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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