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Lysophosphatidic acid receptor 1 (LPA1)

Target Class
GPCR
Family
Lysophospholipid (LPA)
Official Symbol
EDG2
Species
Human
Accession Number
NM_001401.3
Alias Names
LPAR1; EDG2; GPR26; Gpcr26; LPA receptor 1; LPA-1; LPA1; Mrec1.3; VZG1; edg-2; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2; lysophosphatidic acid receptor 1; lysophosphatidic acid receptor Edg-2; rec.1.3; ventricular zone gene 1; vzg-1
Background
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Lysophospholipid (LPA)
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0644C2
Internalization U2OS Human 93-0839C3
cAMP CHO-K1 Human 95-0135C2
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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