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Chemokine (C-X-C motif) receptor 4 (CXCR4)

Target Class
GPCR
Family
Chemokine
Official Symbol
CXCR4
Species
Human
Accession Number
AY242129
Alias Names
C-X-C chemokine receptor type 4; CD184; CD184 antigen; CXC-R4; CXCR-4; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; SDF-1 receptor; WHIM; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C motif), receptor 4 (fusin); fusin; leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; stromal cell-derived factor 1 receptor
Background
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Chemokine
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin C2C12 Human 93-0203C7
Internalization U2OS Human 93-0890C3
cAMP CHO-K1 Human 95-0081C2
Assay Readout Background Species Assay Kit
cAMP CHO-K1 Human 95-0081E2CP2S
cAMP CHO-K1 Human 95-0081E2CP2M
cAMP CHO-K1 Human 95-0081E2CP2L
Internalization U2OS Human 93-0890E3CP5S
Internalization U2OS Human 93-0890E3CP5M
Internalization U2OS Human 93-0890E3CP5L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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