CXCR4 -

Targets

Chemokine (C-X-C motif) receptor 4 (CXCR4)

Target Class

GPCR

Family

Chemokine

Official Symbol

CXCR4

Species

Human

Accession Number

AY242129

Alias Names

C-X-C chemokine receptor type 4; CD184; CD184 antigen; CXC-R4; CXCR-4; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; SDF-1 receptor; WHIM; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C motif), receptor 4 (fusin); fusin; leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; stromal cell-derived factor 1 receptor

Background

This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

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Related Family Members:

Chemokine

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