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Chemokine (C-X-C motif) receptor 2 (CXCR2)

Target Class
GPCR
Family
Chemokine
Official Symbol
CXCR2
Species
Human
Accession Number
NM_001557
Alias Names
C-X-C chemokine receptor type 2; CD182; CDw128b; CMKAR2; CXC-R2; CXCR-2; CXCR2 gene for IL8 receptor type B; GRO/MGSA receptor; IL-8 receptor type 2; IL-8R B; IL8R2; IL8RA; IL8RB; chemokine (C-X-C motif) receptor 2; chemokine (CXC) receptor 2; high affinity interleukin-8 receptor B; interleukin 8 receptor B; interleukin 8 receptor type 2; interleukin 8 receptor, beta; interleukin-8 receptor type B
Background
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
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Solution Portfolio

Related Family Members:

Chemokine
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin HEK 293 Human 93-0202C1
β-Arrestin CHO-K1 Human 93-0202C2
cAMP CHO-K1 Human 95-0074C2
Internalization U2OS Human 93-0934C3
Assay Readout Background Species Assay Kit
cAMP CHO-K1 Human 95-0074E2CP2S
cAMP CHO-K1 Human 95-0074E2CP2M
cAMP CHO-K1 Human 95-0074E2CP2L
β-Arrestin CHO-K1 Human 93-0202E2CP0S
β-Arrestin CHO-K1 Human 93-0202E2CP0M
β-Arrestin CHO-K1 Human 93-0202E2CP0L
Internalization U2OS Human 93-0934E3CP5S
Internalization U2OS Human 93-0934E3CP5M
Internalization U2OS Human 93-0934E3CP5L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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