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prostaglandin D2 receptor 2 (PTGDR2)

Target Class
GPCR
Family
Prostanoid
Official Symbol
CRTH2
Species
Human
Accession Number
AY507142
Alias Names
CD294; CRTH2; DL1R; DP2; G protein-coupled receptor 44; G-protein coupled receptor 44; GPR44; chemoattractant receptor homologous molecule expressed on T helper type 2 cells; chemoattractant receptor-homologous molecule expressed on TH2 cells; prostaglandin D2 receptor 2; putative G-protein coupled receptor 44
Background
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity).
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Solution Portfolio

Related Family Members:

Prostanoid
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0291C2
β-Arrestin U2OS Human 93-0559C3
cAMP CHO-K1 Human 95-0072C2
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0291E2CP2S
β-Arrestin CHO-K1 Human 93-0291E2CP2M
β-Arrestin CHO-K1 Human 93-0291E2CP2L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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