Cannabinoid receptor 1 (CB1)
- Target Class
- GPCR
- Family
- Cannabinoid
- Official Symbol
- CNR1
- Species
- Human
- Accession Number
- AY225225
- Alias Names
- CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR; cannabinoid receptor 1; cannabinoid receptor 1 (brain); central cannabinoid receptor
- Background
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
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Solution Portfolio
Related Family Members:
Cannabinoid
?
DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| cAMP |
CHO-K1 |
Human |
95-0071C2 |
| β-Arrestin |
CHO-K1 |
Human |
93-0959C2 |
| Assay Qualified With |
Assay Measures |
Background |
Species |
Assay Kit |
| CP 55,940 |
β-Arrestin |
CHO-K1 |
Human |
93-0959Y2-00119 |
| CP 55,940 |
β-Arrestin |
CHO-K1 |
Human |
93-0959Y2-00120 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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