Chemokine-like receptor 1 (CMKLR1)

Target Class
Official Symbol
Accession Number
Alias Names
CHEMERINR; ChemR23; DEZ; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ; chemokine receptor-like 1; chemokine-like receptor 1; orphan G-protein coupled receptor, Dez
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
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Solution Portfolio

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Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0313C2
cAMP CHO-K1 Human 95-0080C2
Internalization U2OS Human 93-0720C3
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0313E2CP0M
β-Arrestin CHO-K1 Human 93-0313E2CP0L
cAMP CHO-K1 Human 95-0080E2CP2M
cAMP CHO-K1 Human 95-0080E2CP2L
Internalization U2OS Human 93-0720E3CP22M
Internalization U2OS Human 93-0720E3CP22L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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