Find a Product

Chemokine-like receptor 1 (CMKLR1)

Target Class
GPCR
Family
Chemerin
Official Symbol
CMKLR1
Species
Human
Accession Number
NM_004072.2
Alias Names
CHEMERINR; ChemR23; DEZ; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ; chemokine receptor-like 1; chemokine-like receptor 1; orphan G-protein coupled receptor, Dez
Background
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
+ Show More

Solution Portfolio

Related Family Members:

Chemerin
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0313C2
cAMP CHO-K1 Human 95-0080C2
Internalization U2OS Human 93-0720C3
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0313E2CP0S
β-Arrestin CHO-K1 Human 93-0313E2CP0M
β-Arrestin CHO-K1 Human 93-0313E2CP0L
cAMP CHO-K1 Human 95-0080E2CP2S
cAMP CHO-K1 Human 95-0080E2CP2M
cAMP CHO-K1 Human 95-0080E2CP2L
Internalization U2OS Human 93-0720E3CP22S
Internalization U2OS Human 93-0720E3CP22M
Internalization U2OS Human 93-0720E3CP22L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
The DiscoveRx Advantage:
Access your Target with Three Signaling Platforms