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Cholinergic receptor, muscarinic 4 (M4)

Target Class
GPCR
Family
Acetylcholine
Official Symbol
CHRM4
Species
Human
Accession Number
NM_000741.2
Alias Names
HM4; M4R; acetylcholine receptor, muscarinic 4; cholinergic receptor, muscarinic 4; muscarinic acetylcholine receptor M4
Background
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Acetylcholine
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0349C2
Internalization U2OS Human 93-0902C3
cAMP CHO-K1 Human 95-0145C2
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0349E2CP0S
β-Arrestin CHO-K1 Human 93-0349E2CP0M
β-Arrestin CHO-K1 Human 93-0349E2CP0L
Internalization U2OS Human 93-0902E3CP0S
Internalization U2OS Human 93-0902E3CP0M
Internalization U2OS Human 93-0902E3CP0L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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