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Cholinergic receptor, muscarinic 2 (M2)

Target Class
GPCR
Family
Acetylcholine
Official Symbol
CHRM2
Species
Human
Accession Number
AF498916
Alias Names
7TM receptor; HM2; acetylcholine receptor, muscarinic 2; cholinergic receptor, muscarinic 2; cholinergic receptor, muscarinic 2, isoform a; muscarinic M2 receptor; muscarinic acetylcholine receptor M2
Background
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Acetylcholine
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0198C2
Internalization U2OS Human 93-0656C3
cAMP CHO-K1 Human 95-0078C2
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0198E2CP0S
β-Arrestin CHO-K1 Human 93-0198E2CP0M
β-Arrestin CHO-K1 Human 93-0198E2CP0L
Internalization U2OS Human 93-0656E3CP5S
Internalization U2OS Human 93-0656E3CP5M
Internalization U2OS Human 93-0656E3CP5L
cAMP CHO-K1 Human 95-0078E2CP2S
cAMP CHO-K1 Human 95-0078E2CP2M
cAMP CHO-K1 Human 95-0078E2CP2L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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