Chemokine (C-C motif) receptor 5 (CCR5)
- Target Class
- GPCR
- Family
- Chemokine
- Official Symbol
- CCR5
- Species
- Human
- Accession Number
- BC038398
- Alias Names
- C-C chemokine receptor type 5; C-C motif chemokine receptor 5 A159A; CC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5; CKR5; CMKBR5; HIV-1 fusion coreceptor; IDDM22; chemokine (C-C motif) receptor 5; chemokine (C-C motif) receptor 5 (gene/pseudogene); chemokine receptor CCR5; chemr13
- Background
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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Solution Portfolio
Related Family Members:
Chemokine
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
CHO-K1 |
Human |
93-0224C2 |
| Internalization |
U2OS |
Human |
93-0653C3 |
| cAMP |
CHO-K1 |
Human |
95-0068C2 |
|
Chem-1 |
Rhesus macaque |
HTS010C |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
| |
|
|
|
Available |
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