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Chemokine (C-C motif) receptor 10 (CCR10)

Target Class
GPCR
Family
Chemokine
Official Symbol
CCR10
Species
Human
Accession Number
AY429103
Alias Names
C-C CKR-10; C-C chemokine receptor type 10; CC chemokine receptor 10; CC-CKR-10; CCR-10; G protein-coupled receptor 2; G-protein coupled receptor 2; GPR2; chemokine (C-C motif) receptor 10
Background
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]
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Solution Portfolio

Related Family Members:

Chemokine
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin U2OS Human 93-0276C3
Internalization U2OS Human 93-0783C3
cAMP CHO-K1 Human 95-0175C2
Assay Readout Background Species Assay Kit
β-Arrestin U2OS Human 93-0276E3CP5S
β-Arrestin U2OS Human 93-0276E3CP5M
β-Arrestin U2OS Human 93-0276E3CP5L
Internalization U2OS Human 93-0783E3CP5S
Internalization U2OS Human 93-0783E3CP5M
Internalization U2OS Human 93-0783E3CP5L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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