CCR1 -

Targets

Chemokine (C-C motif) receptor 1 (CCR1)

Target Class

GPCR

Family

Chemokine

Official Symbol

CCR1

Species

Human

Accession Number

NM_001295

Alias Names

C-C CKR-1; C-C chemokine receptor type 1; CC-CKR-1; CCR-1; CD191; CKR-1; CKR1; CMKBR1; HM145; LD78 receptor; MIP-1alpha-R; MIP1aR; RANTES receptor; RANTES-R; SCYAR1; chemokine (C-C motif) receptor 1; macrophage inflammatory protein 1-alpha receptor

Background

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

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Related Family Members:

Chemokine

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family