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Chemokine (C-C motif) receptor 1 (CCR1)

Target Class
GPCR
Family
Chemokine
Official Symbol
CCR1
Species
Human
Accession Number
NM_001295
Alias Names
C-C CKR-1; C-C chemokine receptor type 1; CC-CKR-1; CCR-1; CD191; CKR-1; CKR1; CMKBR1; HM145; LD78 receptor; MIP-1alpha-R; MIP1aR; RANTES receptor; RANTES-R; SCYAR1; chemokine (C-C motif) receptor 1; macrophage inflammatory protein 1-alpha receptor
Background
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Chemokine
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0254C2
Internalization U2OS Human 93-0651C3
β-Arrestin U2OS Human 93-0254C3
cAMP CHO-K1 Human 95-0066C2
Assay Readout Background Species Assay Kit
Internalization U2OS Human 93-0651E3CP5S
Internalization U2OS Human 93-0651E3CP5M
Internalization U2OS Human 93-0651E3CP5L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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