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Calcium-sensing receptor (CaS)

Target Class
GPCR
Family
Calcium sensing
Official Symbol
CASR
Species
Human
Accession Number
NM_000388.3
Alias Names
CAR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; NSHPT; PCAR1; calcium-sensing receptor; extracellular calcium-sensing receptor; hypocalciuric hypercalcemia 1; parathyroid Ca(2+)-sensing receptor 1; parathyroid cell calcium-sensing receptor
Background
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Calcium sensing
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
Calcium U2OS Human 95-1014C3
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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