Calcium-sensing receptor (CaS)
- Target Class
- GPCR
- Family
- Calcium sensing
- Official Symbol
- CASR
- Species
- Human
- Accession Number
- NM_000388.3
- Alias Names
- CAR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; NSHPT; PCAR1; calcium-sensing receptor; extracellular calcium-sensing receptor; hypocalciuric hypercalcemia 1; parathyroid Ca(2+)-sensing receptor 1; parathyroid cell calcium-sensing receptor
- Background
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]
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Solution Portfolio
Related Family Members:
Calcium sensing
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| Calcium |
U2OS |
Human |
95-1014C3 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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