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G-Protein Coupled Receptor 77 (C5L2)

Target Class
GPCR
Family
Complement peptide
Official Symbol
C5L2
Species
Human
Accession Number
NM_018485.1
Alias Names
C5L2; C5a anaphylatoxin chemotactic receptor C5L2; G protein-coupled receptor 77; G protein-coupled receptor C5L2; G-protein coupled receptor 77; GPR77
Background
The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005 [PubMed 16204243]).[supplied by OMIM, Mar 2008]
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Solution Portfolio

Related Family Members:

Complement peptide
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0645C2
Internalization U2OS Human 93-0736C3
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0645E2CP0S
β-Arrestin CHO-K1 Human 93-0645E2CP0M
β-Arrestin CHO-K1 Human 93-0645E2CP0L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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