G-Protein Coupled Receptor 77 (C5L2)
- Target Class
- GPCR
- Family
- Complement peptide
- Official Symbol
- C5L2
- Species
- Human
- Accession Number
- NM_018485.1
- Alias Names
- C5L2; C5a anaphylatoxin chemotactic receptor C5L2; G protein-coupled receptor 77; G protein-coupled receptor C5L2; G-protein coupled receptor 77; GPR77
- Background
The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005 [PubMed 16204243]).[supplied by OMIM, Mar 2008]
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Solution Portfolio
Related Family Members:
Complement peptide
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