Bradykinin receptor B1 (B1)
- Target Class
- GPCR
- Family
- Bradykinin
- Official Symbol
- BDKRB1
- Species
- Human
- Accession Number
- NM_000710.2
- Alias Names
- B1 bradykinin receptor; B1BKR; B1R; BK-1 receptor; BKB1R; BKR1; BRADYB1; bradykinin B1 receptor; bradykinin receptor 1; bradykinin receptor B1
- Background
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
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Solution Portfolio
Related Family Members:
Bradykinin
?
DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
CHO-K1 |
Human |
93-0639C2 |
| Calcium |
CHO-K1 |
Human |
95-1011C2 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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