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Bradykinin receptor B1 (B1)

Target Class
GPCR
Family
Bradykinin
Official Symbol
BDKRB1
Species
Human
Accession Number
NM_000710.2
Alias Names
B1 bradykinin receptor; B1BKR; B1R; BK-1 receptor; BKB1R; BKR1; BRADYB1; bradykinin B1 receptor; bradykinin receptor 1; bradykinin receptor B1
Background
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
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Solution Portfolio

Related Family Members:

Bradykinin
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout ▲BackgroundSpeciesCell Line
CalciumCHO-K1Human95-1011C2
β-ArrestinCHO-K1Human93-0639C2
 
Assay Readout ▲BackgroundSpeciesAssay Kit
β-ArrestinCHO-K1Human93-0639E2CP2S
β-ArrestinCHO-K1Human93-0639E2CP2M
β-ArrestinCHO-K1Human93-0639E2CP2L
 
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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