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Brain-specific angiogenesis inhibitor 1 (BAI1)

Target Class
GPCR
Family
Class B Orphan
Official Symbol
BAI1
Species
Human
Accession Number
NM_001702.2
Alias Names
GDAIF; brain-specific angiogenesis inhibitor 1
Background
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Class B Orphan
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Arrestin Assays
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Assay Ready Kits
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DiscoveRx Assay Ready kits are ready-to-ship, ready-to-use kits that contain all the necessary reagents to perform a functional whole-cell assay including frozen pre-validated cells, detection reagents, media and plates, with a simple thaw-plate-read protocol. DiscoveRx offers a variety of Assay Ready kits. Learn more about our Assay Ready Kits.

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β-Arrestin-2 CHO-K1 93-0545C2 Yes
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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