Vasopressin receptor 2 (V2)

Target Class
Vasopressin and Oxytocin
Official Symbol
Accession Number
Alias Names
ADHR; AVPR V2; DI1; DIR; DIR3; NDI; V2R; antidiuretic hormone receptor; arginine vasopressin receptor 2; renal-type arginine vasopressin receptor; vasopressin V2 receptor
This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Vasopressin and Oxytocin

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family

Assay Readout Background Species Cell Line
β-Arrestin HEK 293 Human 93-0187C1
β-Arrestin CHO-K1 Human 93-0588C2
Internalization U2OS Human 93-0709C3
cAMP CHO-K1 Human 95-0150C2
Assay Readout Background Species Assay Kit
cAMP CHO-K1 Human 95-0150E2CP2M
cAMP CHO-K1 Human 95-0150E2CP2L
β-Arrestin CHO-K1 Human 93-0588E2CP0M
β-Arrestin CHO-K1 Human 93-0588E2CP0L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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