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Apelin receptor (APJ)

Target Class
GPCR
Family
Apelin
Official Symbol
AGTRL1
Species
Human
Accession Number
NM_005161
Alias Names
AGTRL1; APJ; APJ (apelin) receptor; APJ receptor; APJR; G protein-coupled receptor APJ; G-protein coupled receptor APJ; G-protein coupled receptor HG11; HG11; HG11 orphan receptor; angiotensin II receptor-like 1; angiotensin receptor-like 1; apelin receptor
Background
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]
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Solution Portfolio

Related Family Members:

Apelin
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0250C2
Internalization U2OS Human 93-0710C3
cAMP CHO-K1 Human 95-0147C2
β-Arrestin CHO-K1 Human 93-1050C2
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0250E2CP0S
β-Arrestin CHO-K1 Human 93-0250E2CP0M
β-Arrestin CHO-K1 Human 93-0250E2CP0L
Internalization U2OS Human 93-0710E3CP0S
Internalization U2OS Human 93-0710E3CP0M
Internalization U2OS Human 93-0710E3CP0L
cAMP CHO-K1 Human 95-0147E2CP2S
cAMP CHO-K1 Human 95-0147E2CP2M
cAMP CHO-K1 Human 95-0147E2CP2L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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