Apelin receptor (APJ)
- Target Class
- GPCR
- Family
- Apelin
- Official Symbol
- AGTRL1
- Species
- Human
- Accession Number
- NM_005161
- Alias Names
- AGTRL1; APJ; APJ (apelin) receptor; APJ receptor; APJR; G protein-coupled receptor APJ; G-protein coupled receptor APJ; G-protein coupled receptor HG11; HG11; HG11 orphan receptor; angiotensin II receptor-like 1; angiotensin receptor-like 1; apelin receptor
- Background
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]
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Solution Portfolio
Related Family Members:
Apelin
?
DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Qualified With |
Assay Measures |
Background |
Species |
Assay Kit |
| Apelin-13 |
β-Arrestin |
CHO-K1 |
Human |
93-0250Y2-00121 |
| Apelin-13 |
β-Arrestin |
CHO-K1 |
Human |
93-0250Y2-00122 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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