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Adrenergic receptor beta 2 (β2-adrenoreceptor)

Target Class
GPCR
Family
Adrenoceptors
Official Symbol
ADRB2
Species
Human
Accession Number
NM_000024
Alias Names
ADRB2R; ADRBR; B2AR; BAR; BETA2AR; adrenergic, beta-2-, receptor, surface; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; catecholamine receptor
Background
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Adrenoceptors
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0182C2
Internalization HEK 293 Human 93-0800C1
cAMP CHO-K1 Human 95-0121C2
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0182E2CP0S
β-Arrestin CHO-K1 Human 93-0182E2CP0M
β-Arrestin CHO-K1 Human 93-0182E2CP0L
Internalization HEK 293 Human 93-0800E1CP0S
Internalization HEK 293 Human 93-0800E1CP0M
Internalization HEK 293 Human 93-0800E1CP0L
cAMP CHO-K1 Human 95-0121E2CP2S
cAMP CHO-K1 Human 95-0121E2CP2M
cAMP CHO-K1 Human 95-0121E2CP2L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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