ADRB2 -

Targets

Adrenergic receptor beta 2 (β2-adrenoreceptor)

Target Class

GPCR

Family

Adrenoceptors

Official Symbol

ADRB2

Species

Human

Accession Number

NM_000024

Alias Names

ADRB2R; ADRBR; B2AR; BAR; BETA2AR; adrenergic, beta-2-, receptor, surface; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; catecholamine receptor

Background

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]

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Related Family Members:

Adrenoceptors

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