Adrenergic receptor beta 2 (β2-adrenoreceptor)
- Target Class
- GPCR
- Family
- Adrenoceptors
- Official Symbol
- ADRB2
- Species
- Human
- Accession Number
- NM_000024
- Alias Names
- ADRB2R; ADRBR; B2AR; BAR; BETA2AR; adrenergic, beta-2-, receptor, surface; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; catecholamine receptor
- Background
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]
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Solution Portfolio
Related Family Members:
Adrenoceptors
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| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
CHO-K1 |
Human |
93-0182C2 |
| Internalization |
HEK 293 |
Human |
93-0800C1 |
| cAMP |
CHO-K1 |
Human |
95-0121C2 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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